Resource Library Videos Downloadable Resources Breadcrumb Home Resource Library Videos Follow the Sample RNA-based NGS workflow for NTRK gene fusion detection Follow a tumor sample from biopsy to test report using RNA-based NGS testing. Review the testing workflow at the Providence St. Joseph Health Molecular Genomics Laboratory. Close All Toggle dropdown Videos filtered by: Tracking Oncogenesis 2020-10-28 Tracking Oncogenesis The role of NTRK gene fusions in tumor cell survival Take a closer look at how NTRK gene fusions are created and how the fusions promote aberrant oncogenic signaling pathways that promote cell proliferation and survival. Looking at the TRK Record 2020-10-28 Looking at the TRK Record History of oncogenic NTRK gene fusions Learn about the milestones for NTRK gene fusion identification—from its discovery in colon cancer to its current implications. Watch Dr Jessica Davis review this timeline. TRKing Down Gene Fusions 2020-10-28 TRKing Down Gene Fusions The challenges of NTRK gene fusion detection Detecting NTRK gene fusions is challenging due to the many considerations that must be taken into account when choosing a testing methodology. Review the challenges with Dr Michelle Shiller. Considerations and Capabilities 2020-10-28 Considerations and Capabilities Selecting a testing method for NTRK gene fusion detection Current testing methods for NTRK gene fusions offer varying levels of identification and capabilities. What determines which diagnostic testing methodology can deliver best on your objective? Watch Dr Alexander Lazar to find out. FISHing for <i>NTRK</i> 2020-10-29 FISHing for NTRK Considerations for NTRK gene fusions detection using FISH testing Find out when FISH testing is best utilized to detect NTRK gene fusions and what this method’s tissue requirements are. Drs Jessica Davis and Erin Rudzinski take a closer look. Covering Your TRKs 2020-10-28 Covering Your TRKs Pan-TRK IHC as a screening tool for TRK protein expression Learn about the key considerations when deciding when to use pan-TRK IHC as a screening tool for TRK fusion. Dr Erin Rudzinski explains these considerations. Amplification or Hybridization? 2020-10-28 Amplification or Hybridization? Comparing target enrichment techniques for NTRK gene fusion detection When selecting a tumor enrichment approach for NGS, understanding the complexity of your target alteration is key. Dr Michelle Shiller discusses the pros and cons of amplification vs hybridization. Keeping TRK of Technology 2020-10-28 Keeping TRK of Technology Understanding the 5 NGS methodologies What are the key distinctions among NGS approaches for sequence data collection? Review the 5 common ones with Dr Alexander Lazar. RNA- vs DNA-based NGS 2020-10-28 RNA- vs DNA-based NGS Is there a right track for NTRK? Which testing methodology is the best path to follow to identify NTRK gene fusions? Dr Andrew Turk weighs in on RNA- vs DNA-based NGS testing. Considerations for Selecting a Kit 2020-10-28 Considerations for Selecting a Kit For NTRK gene fusion See how things, such as platform and in-house expertise, factor into deciding which commercial NGS kit to select according to Dr Jessica Davis. When Tissue Is the Issue 2020-10-28 When Tissue Is the Issue Ensuring an adequate sample for NTRK gene fusion testing How critical is the quality of a sample to the testing process? Dr Andrew Turk discusses ways to ensure that the tissue is sufficient for testing. Staying on TRK 2020-10-28 Staying on TRK Optimizing turnaround time Learn about the different methods for optimizing turnaround time to obtain timely results for patients. Drs Michelle Shiller and Erin Rudzinski discuss the importance of collaboration between anatomic and molecular pathology. Video Categories (field_video_categories) All Videos filtered by: Videos filtered by: NGS, next-generation sequencing; NTRK, neurotrophic tyrosine receptor kinase; TRK, tropomyosin receptor kinase. Downloadable Resources hidden link for autofocus Download the TRK Fusion Cancer flashcard This flashcard identifies NTRK gene fusions in various tumor types and shows the impact of NTRK gene fusions on cancer care. hidden link for autofocus Download Resource Please enter your information below. Fields marked with an (*) are required. 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Please see our Privacy Statement here. Leave this field blank Download the TRK Fusion Cancer flashcard This flashcard identifies NTRK gene fusions in various tumor types and shows the impact of NTRK gene fusions on cancer care. NGS, next-generation sequencing; NTRK, neurotrophic tyrosine receptor kinase; TRK, tropomyosin receptor kinase.